The plot of Children of the Corn: Runaway follows a young pregnant Ruth who escapes a murderous child cult in a small Midwestern town. She spends the next decade living anonymously in an attempt to spare her son the horrors that she experienced as a child. She lands in the small Oklahoma town, but something is following her. Now, she must confront this evil or lose her child.

Detectives Sean and David Carter are on the case, to hunt down a gruesome serial killer terrorising the city. Joining forces with Detective Christine Egerton, they dig deeper into a spiralling maze of horror that may not be of this world. Could the judgement awaiting the killer's victims also be waiting for Sean?